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Acta Biomater. 5, 249-256 (2009) [pdf] | ||
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Hemocompatibility of Surface-modified Silicon-incorporated Diamond-like Carbon Films |
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Ritwik K. Roy, Heon Woong Choi, Jin Woo Yi, Myoung-Woon Moon,
Kwang-Ryeol Lee, Dong Keun Han, Ji Hoon Shin, A. Kamijo, T. Hasebe |
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The hemocompatibility of plasma-treated Si-incorporated diamond-like carbon (Si–DLC) films was investigated. The Si–DLC films of Si concentration 2 at. % were prepared on Si (100) or nitinol substrates using a capacitively coupled radio frequency plasma assisted chemical vapor deposition (r.f.-PACVD) method using a mixed gas of benzene (C6H6) and diluted silane (SiH4:H2 = 10:90). The Si–DLC films were then treated with O2, CF4, or N2 glow discharge for surface modification. The plasma treatment revealed an intimate relationship between the polar component of the surface energy and its hemocompatibility. All in vitro characterizations such as protein absorption behavior, activated partial thromboplastin time (aPTT) measurement and platelet adhesion behavior showed improved hemocompatibility of the N2-- or O2-plasma-treated surfaces where the polar component of the surface energy was significantly increased. Si–O or Si–N surface bonds played an important role in improving hemocompatibility, as observed in a model experiment. These results support the importance of a negatively charged polar component of the surface in inhibiting fibrinogen adsorption and platelet adhesion. | ||
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